The death, attributed to grief, of the cartoonist and filmmaker Marjane Satrapi, author of Persepolis, has brought back a recurring and widely studied question in the public imagination: is it possible to die of grief? Regardless of Satrapi’s personal circumstances — which remain unknown for now — science points to yes, while reframing the romantic idea within a biological explanation. For example, intense bereavement can worsen mental health, trigger cardiovascular problems and, ultimately, raise the risk of death. Satrapi’s family said on Tuesday that she died “of sadness a little more than a year after the death of Mattias Ripa, her husband and the love of her life.” They gave no further details.

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