Bosses of M&S, Sainsbury’s and Tesco among those writing to Starmer that the ‘ladder of opportunity’ is wobbling

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Some of the UK’s biggest retailers are planning to write to the prime minister urging him to tackle the youth unemployment crisis, with signatories expected to include the bosses of Marks & Spencer, Sainsbury’s and Tesco.

Lobby group the British Retail Consortium said it had drafted a letter to Keir Starmer calling for action, and is circulating it among its 200 members, which include all the main UK retailers (with the exception of Games Workshop) as well as smaller shops. The letter is expected to be published on Wednesday.

Nuvalent’s late-stage lung cancer treatments zidesamtinib and neladalkib are expected to launch later this year

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GSK’s new boss, Luke Miels, has struck one of the British drugmaker’s biggest deals, announcing the $10.6bn (£7.9bn) acquisition of a US cancer specialist with two late-stage medications.

The FTSE 100 company is increasing its oncology portfolio by agreeing to buy Nuvalent, a Boston-based biotech company that develops cancer drugs, including three for lung cancer. GSK will pay $124 a share in cash.